BioSolveIT GmbH

Category: Content
Type: Youtube Video

Generated 3 weeks ago

New videos detected

  • webinar rec: structure-based discovery of new chemical scaffolds acting as p38α MAPK inhibitors

    p38α mitogen-activated protein kinase (MAPK) is an important molecular switch involved in the regulation of many pathways, such as pro-inflammatory signaling networks and cytokines biosynthesis. A large number of small molecules inhibiting p38α MAPK are described in literature; however, as no FDA drugs against this protein are present in the market, the identification of new p38α MAPK inhibitors i...

BioSolveIT GmbH

Category: Content
Type: Youtube Video

Generated 1 month ago

New videos detected

  • webinar recording: fragment-based drug discovery in an integrated informatics environment

    From the outset, Astex have committed to developing a highly integrated informatics platform for fragment-based drug discovery. This ensures scientists from all disciplines have all relevant data at their fingertips, and creates an environment that democratizes the drug-discovery process. Here, we will discuss a number of tools that we have developed to achieve this. These range from chemoinformat...

  • webinar recording: early drug discovery experiences from a small biotech

    The remit of MRC Technology, a charity and small biotech, is to help accelerate the process of target validation and generating tool compounds for enabling further exploration of new targets (as proposed by various academic collaborators in the UK and across the world). Essentially this means MRC T primarily focuses on hit/lead discovery for challenging targets and hence they normally encounter pr...

  • webinar recording: structure-based design of riboswitch and kinase ligands

    Structure-based ligand design is an integral part of modern drug discovery. However, depending on how established a target is, different challenges arise. An example for targets with little present for drug discovery a riboswitches. Riboswitches are cis-acting gene regulatory elements which are part of the .5' untranslated region of mRNAs. As they occur mainly in bacteria they are sought to be tar...

  • webinar recording: on the origins of three-dimensionality in drug-like molecules

    Many medicinal chemistry-relevant structures and core scaffolds tend toward geometric planarity, which hampers the optimization of physicochemical properties desirable in drug-like molecules. As challenging drug target classes emerge, the exploitation of molecular three-dimensionality in lead optimization is becoming increasingly important. While recent interest has emphasized the importance of en...

BioSolveIT GmbH

Category: Content
Type: Youtube Video

Generated 5 months ago

New videos detected

  • webinar recording: computational design of Glycomimetic inhibitors — prospects and limitations

    Carbohydrates represent the most abundant class of molecules in nature and are involved in inflammation, cancer, and infectious disease. Consequently, the design of molecules that mimic structural features of carbohydrates but have improved drug-like properties such as increased affinity, serum half-life, stability, and bioavailability has gained growing attention over recent years. In this webina...

BioSolveIT GmbH

Category: Content
Type: Youtube Video

Generated 7 months ago

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