Cytoskeleton, Inc

Category: Content
Type: Blog Article

Generated 1 day ago

New blog articles detected

  • Citation Spotlight: Characterization of Novel 3D In Vitro Model of Cancer Cell Invasion

    Composition and architecture of extracellular matrix (ECM). Basement membrane is a type of ECM composed of laminin and collagen IV fibers embedded within a collagen I-enriched ECM. FNR01 image overlay with phase contrast background. Fluorescent fibronectin (Cat. # FNR01) treated MCF10A cells (image kindly provided by A. Varadara and M. Karthykenyan, Univ. S.Carolina, Columbia, S...

Cytoskeleton, Inc

Category: Content
Type: Blog Article

Generated 1 week ago

New blog articles detected

  • New 2017 Cytoskeleton Minicatalog

    Click Here to Download New Products, New Discoveries! Signal Seeker Kits New SUMO Kits and More! GOBlot™ Western Blot Processor New Colors Available! Spirochrome Live Cell Reagents New Far-Red Probes!   Legend: Rac1 GTPase cycle regulation by phosphorylation New SUMO Signal Seeker™ Kit and More! The functional component of the SUMO 2/3 Enrichment Kit is an anti-SUMO-...

Cytoskeleton, Inc

Category: Content
Type: Blog Article

Generated 3 weeks ago

New blog articles detected

  • Citation Spotlight: Rac1 GTPase activity: Role in Lung Cancer Proliferation, Migration, and Metastasis

    Swiss 3T3 cell stained with anti-vinculin (red), DAPI (blue nucleus) and F-actin is stained with Acti-stain™ 488 (green F-actin stress fibers, Cat.# PHDG1). Recently, Jeganathan et al. examined the role of intersectin-1s (ITSN-1s) in lung cancer proliferation, migration, and metastasis. These cellular processes require actin cytoskeleton re-arrangement typically regulated by...

  • Citation Spotlight: Rho-Family GTPase Activity: Key Components of Anti-Inflammatory and Neuroprotective Pathway

    Rac activation in Swiss 3T3 fibroblasts. F-actin is visualized with fluorescent green phalloidin staining (Cat.# PHDG1). DAPI is the blue nuclear stain. Phalloidin staining shows F-actin-rich lamellipodia. Cells were activated with Cat.# CN04. Recently, Rom et al. examined molecular pathways involved in leukocyte-mediated neuroinflammation given its causative role in neurona...

  • Custom Services Newsletter: Rho Family GTPases and Central Nervous System Injuries, Diseases, and Disorders

    Click to view this newsletter.  Effective treatments for central nervous system (CNS) injuries, diseases, and disorders remain a serious challenge for preclinical research scientists and clinicians This newsletter discusses some compounds that are in clinical trials or proteins/pathways that warrant consideration as therapeutic targets. Click to read more   Also included in this newslet...

  • November/December Newsletter: Small molecule inhibitors of GEF-mediated GTPase signaling

    Click to view this newsletter.  Ras and Rho-family GTPases regulate multiple cellular processes, including development, growth, motility, intracellular trafficking, gene expression, and the cell cycle1,2. Moreover, dysfunction of these GTPase are correlated with several human diseases (e.g., cancer, neurodegeneration, bacterial pathogenesis)3-5. Like all GTPases, Ras and Rho GTPase...

  • Citation Spotlight: Novel Tubulin Polymerization Inhibitor and Multidrug Resistance

    Crystal structure of tubulin-stathimine-colchicine complex. Recently, Zheng et al. identified and characterized a novel tubulin polymerization inhibitor discovered during anti-cancer compound screenings using the epithelial-mesenchymal transition (EMT)-mimetic assay. The lead compound was a nitrobenzoate molecule (2-morpholin-4-yl-5-nitro-benzoic acid 4-methylsulfanyl-benzyl ester), d...

  • Citation Spotlight: Rho GTPases and epidermal stem cell migration

    Rho activation in Swiss 3T3 fibroblasts. F-actin is visualized with fluorescent green phalloidin staining (Cat.# PHDG1). DAPI is the blue nuclear stain. Phalloidin staining shows F-actin-rich stress fibers. Cells were activated with Cat.# CN04. Recently, Zhan et al. investigated the molecular pathways underlying human epidermal stem cell (hESC) migration during wound repair to better ...

Cytoskeleton, Inc

Category: Content
Type: Blog Article

Generated 4 months ago

New blog articles detected

  • September Newsletter: FtsZ Proteins: A Novel Anti-microbial Target

    Click to view this newsletter.  The tubulin homolog FtsZ (Filamenting temperature-sensitive mutant Z) protein is an essential prokaryotic cell divison protein. FtsZ is a GTPase that polymerizes in a nucleotide-dependent manner head-to-tail to form single-stranded filaments that assemble into a contractile ring called the Z-ring. This ring forms on the inside of the cytoplasmic membrane ...

  • Citation Spotlight: Rho GTPases and SNX9: Cancer Cell Invasion and Metastasis

    RhoGAP activity measured as GTP hydrolysis by RhoA protein. Each reaction contained reaction buffer + GTP with the addition of RhoA alone (RhoA), RhoGAP alone (GAP), or RhoA + RhoGAP (RhoA + GAP). Reactions were incubated at 37°C for 20 min. Phosphate generated by hydrolysis of GTP was measured by the addition of CytoPhos™ reagent and reading of absorbance at 650 nm. Recently, ...

Cytoskeleton, Inc

Category: Content
Type: Blog Article

Generated 6 months ago

New blog posts detected

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